![]() ![]() The exact prevalence of chronic idiopathic nausea or functional vomiting is not well studied and population-based studies are needed to estimate the disease burden.Ĭentral and peripheral pathways involved in pathogenesis of nausea. ![]() In addition, race has also been shown to be associated with differential rates of the experience of nausea with White/African-Americans experiencing less nausea than Asian/Asian-American subjects Ĭhronic, unexplained nausea alone or with vomiting occurs less commonly but is associated with significant comorbidity and poses a therapeutic challenge to providers. Similar results have been reported in other epidemiological studies. In a large population based study of 62651 individuals, 12.5% of the individuals reported nausea as ‘minor or major complaint’ in the last 12 months with the prevalence of nausea being three times higher in women than in men. In population studies, more than 50% of adults reported at least one episode of nausea, and more than 30% of adults reported one episode of vomiting within the preceding 12 months, with women reporting more episodes of nausea than men. ![]() Aside from the economic impact, the psychological toll is also a significant factor. An estimated cost of $4–16 billion to the US economy has been suggested being attributable to nausea and vomiting. In addition, as nausea often coexists with vomiting, epidemiologic data on nausea alone is sparse. Nausea is by definition a subjective sensation which poses an inherent limitation in accurately assessing the resultant economic burden. Neuromuscular disorders of the gastrointestinal tract
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